CELLBONE TECHNOLOGY

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   Ascorbic Acid 2-Glucoside (AA2G)

   - Stabilized Ascorbic Acid

 

Same Benefits of Vitamin C

  Ascorbic Acid 2-Glucoside(AA2G) is natural vitamin C (ascorbic acid) stabilized with glucose. This combination allows the benefits of vitamin C to be conveniently and effectively used in cosmetic products. When creams and lotions containing Ascorbic Acid 2-Glucoside(AA2G) are applied to the skin, an enzyme present in the skin, a-glucosidase, acts on the Ascorbic Acid 2-Glucoside(AA2G) to slowly release the healthful benefits of vitamin C. 

Ascorbic Acid 2-Glucoside(AA2G) was originally developed as a quasi-drug cosmetic product in Japan to lighten the overall tone of the skin and reduce the pigmentation in age spots and freckles. Further research has shown other dramatic benefits and today AA2G is used all over the world not only for whitening but also for brightening dull looking skin, reversing the effects of aging, and in sunscreen products for protection.
 

 

 

High Stability 

 

Ascorbic Acid 2-Glucoside(AA2G) has glucose bound to the hydroxyl group of the second carbon (C2) of the ascorbic acid. The C2 hydroxyl group is the primary site of natural vitamin Cs beneficial activity; however, this is the site where vitamin C is degraded. The glucose protects vitamin C from high temperatures, pH, metal ions and other mechanisms of degradation.
 

Suatainable Vitamin C Activity

  When products containing Ascorbic Acid 2-Glucoside(AA2G)are used on the skin, the action of a-glucosidase gradually releases vitamin C, providing the benefits of vitamin C effectively over a prolonged period of time.
 

For Brighter Skin

 

without Ascorbic Acid 2

Ascorbic Acid 2-Glucoside(AA2G) can function in essentially an identical manner to vitamin C, preventing pigmentation of skin by suppressing melanin synthesis in melanocytes. It also has the ability to reduce the amount of pre-existing melanin, resulting in a lighter pigmentation of the skin.
 

 

 


with Ascorbic Acid 2

The efficacy of Ascorbic Acid 2-Glucoside (AA2G)was tested using B16 melanoma cells treated for 12 hr with Ascorbic Acid 2-Glucoside(AA2G) (2.5mM) or a placebo. Following treatment theophylline (0.5mM) was added to stimulate melanin

For Healthy Skin

Ascorbic Acid 2-Glucoside(AA2G) slowly releases vitamin C, which has been shown to promote the synthesis of collagen by human skin fibroblasts, thereby increasing the suppleness of the skin. AA2G can provide these bene?ts over a prolonged time period.synthesis, and the cells were tested after 48 hr for the presence of DOPA quinone (a precursor to melanin) using a histochemical stain. This shows that Ascorbic Acid 2-Glucoside(AA2G) can prevent unwanted skin pigmentation.
[Yamamoto et al., Nishinihonhifuka, 58 (3), 439-443 (1996)]

Human skin fibroblasts were incubated in the presence of a control, ascorbic acid (AsA; 0.25mM) or Ascorbic Acid 2-Glucoside(AA2G) (0.25mM) for 1- 5 days. The percentage of collagen synthesis to total protein synthesis was determined. This shows that AA2G can promote collagen synthesis. Stimulatory effect of AA2G continued for the full 5 day period.

[Yamamoto et al., J.Nutr., 122, 871-877 (1992)]

For Healthy Skin

Ascorbic Acid 2-Glucoside(AA2G) slowly releases vitamin C, which has been shown to promote the synthesis of collagen by human skin fibroblasts, thereby increasing the suppleness of the skin. AA2G can provide these bene?ts over a prolonged time period.
 

For Sunlight Protection

Oxygen radicals, which are formed in the skin during its exposure to sunlight, are believed to cause skin damage and reddening of the skin. Ascorbic Acid 2-Glucoside(AA2G) slowly releases vitamin C, which acts as a free radical scavenger, thereby reducing the amount of skin inflammation and roughness.

In a controlled test, creams containing 2% Ascorbic Acid 2-Glucoside(AA2G) or placebo were applied at two places on the inside of the right arm of 15 healthy adults. The creams were applied three times a day for 6 consecutive days. During this treatment, the arms were irradiated with UVA and UVB once per day for a total of 3 days. This shows that AA2G can prevent UV skin damage as measured by a reduction in skin erythema.
[Miyai and Yamamoto et al., Nishinihon J.Dermatol., 58 (3), 439 (1996)]

 

For Younger looking Skin

Ascorbic Acid 2-Glucoside(AA2G) slowly releases vitamin C which acts to reduce fine lines and wrinkles, resulting in younger looking skin.
Sixteen female volunteers ranging in age from 37 to 55 years, applied a face cream containing 2%
Ascorbic Acid 2-Glucoside(AA2G). The change in mean depth of the wrinkle profiles was determined using silicone casts at onset and after 45 and 90 days. The results showed that there was a significant difference ( p < 0.01) in reducing the average depth of wrinkles after 45 days of use and these beneficial effects continued with further use.
 

For Younger looking Skin

Ascorbic Acid 2-Glucoside(AA2G) slowly releases vitamin C which acts to reduce fine lines and wrinkles, resulting in younger looking skin.

Sixteen female volunteers ranging in age from 37 to 55 years, applied a face cream containing 2% Ascorbic Acid 2-Glucoside(AA2G). The change in mean depth of the wrinkle profiles was determined using silicone casts at onset and after 45 and 90 days. The results showed that there was a significant difference ( p < 0.01) in reducing the average depth of wrinkles after 45 days of use and these beneficial effects continued with further use.

Sixteen female volunteers ranging in age from 37 to 55 years, applied a face cream containing 2% Ascorbic Acid 2-Glucoside(AA2G). The change in mean roughness profiles was determined using silicone casts at onset and after 45 and 90 days. The results showed that there was a significant difference ( p < 0.01) in reducing the roughness of the skin after 45 days of use and these beneficial effects continued with further use.