Thermus Thermophilus (Venuceane™)
-Protection of cell membrane lipids against UVA rays
Function
Heat Activated strong anti-oxidant
Definition
Biotechnical product obtained the culture of Thermus Thermophilus
Properties
Inhibits radical oxygen species. Repairs and protects against damages caused by UVA.
Characteristics
Thermo-stable, UV-stable, inexhaustible enzyme activity. Increasing efficacy with rising temperature.
Origin
Thermus Thermophlius lives in deep sea, under extreme conditions (2000m depth, 75 degree C temperature, and 200 bars pressure)
In Vitro Tests
Thermus Thermophilus (Venuceane™) displays a similar activity to native skin enzyme scavengers of toxic oxygen species such as super oxide and ion O+-2 hydrogen peroxide H2O2.
Thermus Thermophilus (Venuceane™) detoxifying activity increases with temperature.
In vivo Tests - Protection Agaist memrane lipid peroxidation
UVA irradiation: 15J/cmm2(equivalent to 11/2 hour exposure on a sunny day.
In vivo Tests - Protection against membrane lipid peroxidation
UVA irradiation: 60J/Cm2 Equivalent to 6 hours exposure on a sunny day.
In vivo Tests - Membrane protection of temperature
Model of phospholipid membranes exposed to a dose of 10 J/cm2 of UVA irradiation (equivalent to 1 hour exposure on a sunny day) Measurement of lipid peroxidation.
Thermus Thermopilus (Venuceane™) strongly protects phospholipids from peroxidation.
Thermus Thermopilus (Venuceane™) strongly protects phospholipids from peroxidation.
In vivo Tests - Protection of the skin's natural detoxifying enzymes
Protocol: Application of a gel on the arm for 1 hour
Thermus Thermophilus (Venuceane™) adapts and maintains skin's natural protection much higher than Vitamin E acetate.
Thermus Thermophilus (Venuceane™) adapts and maintains skin's natural protection much higher than Vitamin E acetate.
In vivo Tests - Protection against DNA oxidation
Fluorescence detection of oxidation DNA base Guanine of human fibroblasts with 3% with Vitamin E acetate 0.1% after exposure to 10 J/cm2 UVA (equivalent to 1 hour exposure on a sunny day) Thermus Thermophilus (Venuceane™) protects DNA from oxidation caused by UVA irradiation.
Thermus Thermophilus (Venuceane™) protects DNA from oxidation caused by UVA irradiation.
In vivo Tests - Protection against lipoperoxidation
Model of phospholipid membranes exposed to a dose of 10J/cm2 of UVA irradiation (equivalent to 1 hour exposure on a sunny day)
Thermus Thermophilus (Venuceane™) adapts and maintains skin's natural protection .
Thermus Thermophilus (Venuceane™) adapts and maintains skin's natural protection .
